1. Benadryl, Dramamine, and Lergigan can cure DFP-induced cortical seizures. The action of Phenergan is less consistent while Thephorin, Antistine, Pyribenzamine, Neoantergan, and Chlor-Trimeton failed to eliminate the seizure waves.2. Benadryl, Dramamine, Lergigan, and Phenergan corrected the adversive syndrome (forced circling movements) produced by the injection of subconvulsive doses of DFP. The other 5 antihistamines were without corrective effect.3. The curative abilities of Benadryl, Dramamine, Lergigan, and Phenergan depends upon a cerebral action of these drugs and may be related to an atropine-like quality that is seen to a lesser extent in the other 5 antihistamines.We wish to thank W. G. Esmond, Alice McCauley, and P. D. Bales for cooperating with us in the performance of some of the original experiments (see reference 19).