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THE USE OF ANTABUSE (TETRAETHYLTHIURAMIDISULPHIDE) IN CHRONIC ALCOHOLICS
S. EUGENE BARRERA; WALTER A. OSINSKI; EUGENE DAVIDOFF
Am J Psychiatry 1950;107:8-13.
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The Department of Neurology and Psychiatry, Albany Medical College and Hospital, and The Veterans Administration Mental Hygiene Clinic, Watervliet, N. Y.

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Abstract

1. Fourteen of 21 cases treated with Antabuse abstained from alcohol for periods of 2 to 4 months. Twenty-one cases represent too small a group from which to draw many general conclusions. However, the drug appears to have value in the treatment of chronic alcoholism but it has to be given under controlled conditions and in conjunction with psychotherapy. It appears to be more effective than other drug or conditioned reflex therapies used previously.2. Further coordinate research including internal medical, pharmacologic, psychologic, and social service studies in conjunction with the psychiatric observations are indicated on a greater number of cases to establish the value of the drug. Furthermore, the patients should be studied over a longer period of time, i. e., about a year, to determine the permanency of their abstinence.3. Under controlled conditions no severe untoward effects were noted.

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