1. The technique of combined sub-coma insulin and pentothal narcosis in the treatment of 60 consecutive cases of prolonged anxiety was explained and the results analyzed.2. Especially encouraging results have been obtained where the anxiety reaction has been superimposed upon a previously stable personality.3. Although the superficial anxiety is usually all alleviated, if there have been longstanding emotional conflicts, more prolonged psychotherapy is usually necessary to influence them seriously.4. Sub-coma insulin and pentothal should be looked upon as primarily supportive measures, but definitely serve to promote relaxation and to make the patient more receptive to psychotherapy.5. It is felt that this form of treatment is practical in cases of prolonged anxiety reaction in civilian practice and is especially applicable to the treatment of this type of case on the wards of a general hospital.