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SYMMETRICAL BILATERAL GRANULAR ATROPHY OF THE CEREBRAL CORTEX OF VASCULAR ORIGIN A Clinico-Pathologic Study
ANDREW J. AKELAITIS
Am J Psychiatry 1942;99:447-453.
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The Department of Medicine, Division of Psychiatry, University of Rochester School of Medicine and Dentistry, and the Clinics of the Strong Memorial and Rochester Municipal Hospitals.

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Abstract

A case of symmetrical, bilateral granular atrophy of the cerebral cortex is described. Topographically, the atrophy is limited mainly to those areas lying at the juncture of the vascular supply of the anterior, middle and posterior cerebral arteries.The primary involvement of the gray matter differentiates this form of atrophy from Binswanger's chronic subcortical encephalopathy. In the granular type of atrophy of the cerebral cortex those pial arteries supplying the cortex are mainly involved while in Binswanger's encephalopathy, the arteries supplying the medullary layer are primarily affected.

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