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AMPHETAMINE (BENZEDRINE) SULFATE AS A CORRECTIVE FOR THE DEPRESSION OF SEDATIVE MEDICATION IN EPILEPSY
LEON J. ROBINSON
Am J Psychiatry 1941;98:215-218.
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The Monson State Hospital, Palmer, Mass.

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Abstract

Amphetamine ( benzedrine) sulfate, (5-30 mgm.) was given to 58 epileptic patients with toxic manifestations as a result of increased anti-convulsant medication, the latter consisting mainly or in part of phenobarbital in all but one case, (receiving mebaral alone).The toxic effects of the anti-convulsant medication consisted of drowsiness, ataxia, irritability, aggressiveness, anorexia, vertigo, nystagmus and tremor.Amphetamine (benzedrine) sulfate was notably of value in combating the drowsiness (64.2 per cent of cases); and secondarily of value in relieving ataxia, irritability, aggressiveness and anorexia, associated with the drowsiness.Amphetamine was effective in 39 cases, ineffective in 18 cases. When effective, amphetamine was constantly necessary in 18 patients, and only temporarily necessary (7 days to 2 months) in 21 patients.In itself, amphetamine (benzedrine) sulfate did not affect the incidence of epileptic seizures.By counteracting toxic effects amphetamine (benzedrine) sulfate made it possible, in many cases, to reduce seizures by giving adequate anti-convulsant medication, and in this respect proved of appreciable importance as an adjunct in the therapy of epilepsy.

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