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DETOXICATION OF SODIUM BENZOATE IN NEUROPSYCHIATRIC DISORDERS The Excretion of Hippuric Acid After the Ingestion of Sodium Benzoate.
ISIDORE FINKELMAN; JERRY HORA; IRVING C. SHERMAN; M. K. HORWITT
Am J Psychiatry 1940;96:951-960.
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The Department of Nervous and Mental Diseases, Northwestern University Medical School and the Elgin State Hospital.

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Abstract

The rate of detoxication of benzoic acid was determined in patients with various neuropsychiatric diseases. About one half of the patients with catatonia showed a defect in hippuric acid synthesis. This may be due to the state of muscular rigidity and immobility of these patients. Deteriorated patients with epilepsy showed a defect in the synthesis of hippuric acid, whereas extramural patients with epilepsy showed a normal excretion of the equivalent benzoic acid. This may indicate a defect in glycine synthesis in deteriorated patients with epilepsy. Normal average values were found in post-encephalitic Parkinsonism and multiple sclerosis. A patient with progressive muscular dystrophy was able to synthesize glycine at a normal rate.

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