0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
THE MECHANISM OF THE SYMPTOMS OF INSULIN HYPOGLYCEMIA
H. E. HIMWICH; J. P. FROSTIG; J. F. FAZEKAS; Z. HADIDIAN
Am J Psychiatry 1939;96:371-385.
View Author and Article Information

The Departments of physiology and pharmacology and neurology and psychiatry, Albany Medical College, Union University, Albany, New York, the biological laboratories, Clark University, Worcester, Massachusetts, and Harlem Valley State Hospital, Wingdale, New York.

text A A A
PDF of the full text article.
Abstract

1. Simultaneous observations of clinical symptoms, cerebral oxygen utilization, blood sugar level and electrical activity of the brain were made on patients with schizophrenia receiving the insulin treatment.2. Blood sugar decreases during the first hours after the injection of insulin and then remains at a low level until termination with sugar while the clinical signs continue to develop progressively throughout the entire course of hypoglycemia.3. The march of the symptoms is correlated with a gradual decrease of cerebral oxygen uptake and the electrical changes.4. The regression of the symptoms is accompanied by a gradual increase of the oxygen uptake and a reduction of the delta index. The sequence of the symptoms during regression is in an order which is the reverse of their appearance.5. During hypoglycemia the alpha waves disappear approximately at the time when the functions of the cortex are completely suppressed and reappear with the restoration of cortical functions.6. It is therefore, concluded that as a result of the hypoglycemia caused by the administration of insulin the metabolism of the brain is diminished. This reducton of cerebral metabolism is the cause of the clinical symptoms as well as the alterations of the cerebral electrical activity of the brain.7. These conclusions concerning the correlations between the clinical and physiological changes are to be regarded only as a working hypothesis because of the small number of the experiments performed.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Articles
Topic Collections
Psychiatric News
PubMed Articles