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ANOMALIES AND DANGERS IN THE METRAZOL THERAPY OF SCHIZOPHRENIA
LAWRENCE E. GEESLIN; HERVEY CLECKLEY
Am J Psychiatry 1939;96:183-191.
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The Departments of Internal Medicine and Psychiatry, The University of Georgia School of Medicine, Augusta, Ga.

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Abstract

1. Various motor phenomena bearing little resemblance to the typical grand mal epileptic seizure or to the usual description of the seizure induced by metrazol occasionally occur.2. The possible dangers from protracted tonic reactions secondary to the usual seizures should be kept in mind. The threat of persistent anoxia may under such circumstances become ominous.3. When metrazol therapy is being used every available means should be at hand to combat such developments.4. All anomalous reactions which suggest yet unrecognized complications of metrazol should be reported in detail. Warnings concerning the possibility of such dangers have already been sounded.48 The practice of repeating the metrazol injection within a few minutes, though apparently safe in most cases, is not recommended.

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