Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
Irving J. Sands
Am J Psychiatry 1928;84:975-987.
text A A A
PDF of the full text article.

Epidemic encephalitis is an infectious disease of as yet unknown etiology, but of a well-established pathology. The cerebro-spinal nervous system, especially the brain, bears the brunt of the infection. The anatomical picture is characterized by marked congestion and edema, infiltration of the Virchow-Robin lymph spaces by lymphocytes and plasma cells; distension and occasional rupture of vessels resulting in hemorrhage; moderate cloudy swelling of the ganglion cells with chromatolysis, satillitosis and occasionally neurononphagy; and moderate neuroglia reaction. The pathological process is a changing and progressive one. The mental picture results from the action of the encephalitic virus and inflammatory exudates upon the nerve tissue. The clinical reaction, therefore, may be that of an acute organic psychosis in which there is a constant changing of symptoms. Occasionally the toxemia may bring to the surface deeply rooted mental conflicts, adding a psychogenic coloring to the presenting symptoms. The encephalitic virus may first attack those parts of the brain that control the highest psychic processes (frontal lobes) and may produce a psychosis as the earliest clinical manifestation. The early recognition of these cases are of tremendous medical and sociological importance.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Related Content
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 11.  >
Topic Collections
Psychiatric News
PubMed Articles