The review of two patients presenting the combination or alter-nation of manic-depressive and schizophrenic modes of reaction.The constitution of the patients may have determined to a certain extent the type of their reaction, but early environment and experiences had probably influenced their stability and left their stamp on the later psychoses.A fatalistic emphasis on the congenital endowment is less useful than attention to the moulding environmental factors, the study of which encourages effort in the direction both of prophylaxis and treatment.
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