1. A man whose trouble began with a "shock" at 26, who had numerous convulsions through a period of years and whose neurological symptoms varied from time to time, showed at autopsy an area of gliosis in the left parietal lobe, together with patchy gliosis in the cord. His condition had been diagnosed syphilitic dementia, brain tumor, multiple sclerosis and epilepsy.2. A girl of 19, previously immoral, was found to have spinal fluid changes such as are found in neurosyphilis (except that the Wassermann test was negative), together with marked and varying neurological symptoms. The autopsy showed a meningitis of mild grade, together with an extremely pronounced multiple sclerosis.3. The relationship between the neurosyphilis (?) and the sclerosis is obscure.4. They may stand in the relation of cause and effect, or they may be coincident, or both meningitis and sclerosis may be due to some other cause.5. Two unusual combinations of lesions are presented:A. Large focal lesion of cortical gray matter in multiple sclerosis.B. Combination of meningitis and multiple sclerosis.