This pair of splendid books traces the effect of early-life exposures and genetics to the risk for later psychiatric disease. Both books convey the excitement of scientists who have found a bridge between many seemingly disparate risk factors to a parsimonious model for the origins of mental illness. Alan Brown, a tenacious epidemiological psychiatrist, and Paul Patterson, a benchtop developmental neurobiologist, clearly inspired each other’s scientific pursuits, and now they will inspire many readers with these two fine books. Brown and Patterson jointly edited The Origins of Schizophrenia, a compilation of excellent, independent chapters. Although somewhat technical for the average reader, it will be a treat for any past, current, or future scholar of schizophrenia or anyone interested in the early determinants of brain functioning.