Metformin for Treatment of Antipsychotic-Induced Amenorrhea and Weight Gain in Women With First-Episode Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled Study

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.

From the Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha, China; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Psychiatry, Case Western Reserve and University Hospital Case Medical Center, Cleveland; the Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Illinois at Chicago; and the Hangzhou Seventh People Hospital, Hangzhou, China.