The image on the vase shown here, signed by the Greek-Sicilian vase painter Asteas (350–320 B.C.E.), is one of western civilization's earliest depictions of insanity. It shows a theater performance of Euripides' Herakles (written 425–416 B.C.E.). The center of the picture features Herakles about to immolate his son as Megara, his wife, tries to flee at the far right. Lyssa (upper left), a Greek goddess of madness also called "Mania," has driven Herakles into a state of altered consciousness, during which he will murder his children and wife. Herakles would like to blame Hera for his rampage but expresses his own doubt about the gods' influence: "The gods are indifferent to everything but themselves. I return their indifference." Meagher noted that in this play, the revenge of Hera through the help of Lyssa is a "mythic cover story for the true event(s)" (1, p. 54) and a metaphor for mortal passions.