In chapters 4–7 of their text, the authors seine prominent and prototypical neuropsychiatric conditions through fine nettings of epidemiology, genetics, brain imaging, neuropsychology, neurobiology, and neuropathology in order to capture aspects of the CNS that might be uniquely human. The disorders considered are schizophrenia, bipolar disorder, autism, attention deficit hyperactivity disorder (ADHD), anorexia nervosa, and frontotemporal dementia. Often reconceptualizing the essences of the respective illnesses through recent evolutionary and neurobiologial advances, these explorations are exhilarating. For example, they convincingly posit that ADHD is a primary deficit in motivation rather than a deficit in attention. In making their case, the authors deftly review the recent research revelations about the neurocircuitry, neurogenetics, neurobiology, and neuropathology of the brain's primary reward system—the dopamine system—as it would relate to the symptoms and treatment of patients with ADHD.