In this issue, Anton and colleagues (5), again acknowledging the multifaceted symptoms of alcoholism, report the effect of adding gabapentin to naltrexone in the postdetoxification period. The naltrexone-gabapentin combination makes excellent pharmacological sense, and it is likely to be safe because naltrexone has no significant interactions with any class of drugs other than opioids. During the immediate postdetoxification period, symptoms that can be described as "protracted withdrawal" are prominent in many patients and may cause treatment dropout or relapse to drinking. Naltrexone has not been found to have any effect on such symptoms. Clinicians have always been tempted to add other medications for symptomatic treatment of irritability, insomnia, and anxiety early in alcoholism treatment, and gabapentin seems to be a logical choice. It has already been shown to reduce the symptoms of acute alcohol withdrawal in a controlled study (6).