Beyond keeping pace with the science of psychiatry, many of DSM-5's proposed changes represent an opportunity to improve the field from clinical and public health perspectives. The proposal for a single "autism spectrum disorder" category that would include the current DSM-IV diagnoses of autistic disorder (autism), Asperger's disorder, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified was born from data suggesting that these disorders share a pathophysiological substrate. Changes in the wording of the criteria, however, help clarify symptom manifestation and provide diagnosticians with a more accurate example of how these children actually appear in clinics. Similarly, a proposal from the Psychotic Disorders Work Group for an "attenuated psychosis syndrome" diagnosis was developed largely because of the sizable body of literature on psychosis risk and vulnerability factors detailing structural and functional imaging, neurocognition, and genetic outcomes. Clinically, this proposal may aid clinicians in early detection and intervention for help-seeking individuals at risk for a future psychotic disorder. Our current thinking about criteria specifically and the classification of diagnoses in DSM-5 as a whole is consistent with observations from research on heritability, treatment similarity, and shared genetic risk factors among disorders, including neurodevelopmental disorders, mood disorders, anxiety disorders, and schizophrenia spectrum disorders (7), while also supporting our philosophy that DSM-5 remains first and foremost a tool for clinicians.