However, the importance of this study is not in the results, but in the success of the methods. Identifying ways to conduct neuroimaging with a population that is unable to respond to requests to "lie still" is an important advance. Standard procedures for differentiating white from gray matter are ineffective when the component that makes brain matter white (the myelin) is not yet fully developed, and new analytic models had to be developed. Neonatal brains are developing very rapidly, and the window to successfully obtain a scan is only days to a few weeks long, as compared to the months or even years when studying older children or adults. In addition, pregnancy is a time of rapidly changing and often unstable social support systems, particularly for pregnant women with psychosis, and attrition from studies is expected to be high. When the short participation window is combined with the high attrition rate, recruitment and retention of pregnant psychotic mothers-to-be can be a major obstacle. The report by Gilmore et al. appears to be the first on brain imaging in fetuses and infants that are vulnerable to psychosis, and it reflects successful solutions to several methodological hurdles and gives hope that further investigation will provide additional information on the neurobiological substrate of psychosis vulnerability.