The article by Johnson offers treatment recommendations for three clinical subtypes of alcohol dependence and reviews the evidence in support of the recommendations. The article rightly points out the importance of early identification of at-risk drinkers through standardized screening tools such as the Alcohol Use Disorders Identification Test (AUDIT) recommended by the National Institute on Alcohol Abuse and Alcoholism Clinicians Guide (3). For those who are identified as at-risk drinkers, a more detailed history about the pattern of drinking, associated medical and psychiatric comorbidities, family history, and sufficient clinical information to make a DSM—IV diagnosis should be obtained. In the case of the middle-aged man who has severe chronic alcohol dependence with regular and frequent heavy drinking and medical complications, a trial with topiramate (25—300 μg/day with a target dose of ≥100 mg/day) is recommended. For the young adult man with early-onset drinking, antisocial behavior, binge drinking, and emerging alcohol dependence, low-dose ondansetron (4 mg/kg) or oral naltrexone, up to 100 mg/day, along with brief intervention is considered appropriate. Finally, for an elderly, recently retired woman who feels gloomy and is drinking to alleviate her low mood, long-acting injectable naltrexone, 380 mg once a month for 4 months, is recommended along with brief intervention.