We agree that very little is known about bipolar disorder in preschoolers. Therefore, at the request of parents with bipolar disorder who participated in our school-age study (1), we decided to evaluate their preschool children for psychopathology, including the presence of DSM manic symptoms. After adjusting for several confounding factors (e.g., the child's ADHD symptoms), offspring of parents with bipolar disorder had significantly higher total scores on the Mania Rating Scale relative to offspring of comparison parents. Additionally, in adjusting for multiple comparisons, exploratory analyses showed that between-group differences in manic symptoms were mainly attributable to irritability, elation, decreased need for sleep, and mood lability. However, 96% of the severity scores for manic symptoms were classified as mild or less. Interestingly, these subclinical manic symptoms are similar to the prodromal manic symptoms retrospectively reported in the Amish study. We are in the process of following the children to evaluate the nature of these symptoms and whether they predict an increased risk for mood disorders.