What would it take to transform our failed system? This is a question I began to try to answer recently in a commentary for another journal (1). Perhaps the answer is best understood, especially by clinicians and policy makers, as the gap between what we know and what we do—a gap so wide it continues to astound. But I believe that a fine model for closing the gap is a public health one: identify the populations and diseases where prevalence and burden are great, where solutions (often good if imperfect) exist, and where those solutions (treatments and social interventions) are known but not being sufficiently employed, and then systematically proceed to implement those solutions—person by person, disorder by disorder, community by community, and population by population until we can be assured, by reliable and valid measures, that the gap is closing.