The relationship between depression and diabetes is of special interest in the 21st century since both conditions are major contributors to the global burden of disease. Almost 15 years ago, Eaton and collaborators (1) reported, from the Baltimore Epidemiologic Catchment Area Study, an association between major depressive disorder, but not milder forms of depression, and incident diabetes. This association has been replicated on a number of occasions and supported by the most recent meta-analysis from the Hopkins group, which also extended it to milder forms of depression (1). While the depression-diabetes relationship appears bidirectional, such that diabetes also increases risk for depression, the association in the depression-to-diabetes direction appears stronger than the inverse (2, 3). Further, this association has been replicated across several ethnic and racial groups, including Caucasians, African Americans, Hispanics, and Chinese (3). Hence, the existence of a link between depression and the later onset of diabetes is well established.