The study's findings remind me of the effects of selective serotonin reuptake inhibitors (SSRIs) on anger, which I have observed in patients with combat-related posttraumatic stress disorder (PTSD). I've noted that treatment with SSRIs often produces a discernible reduction in observed and internally experienced anger preceding any reduction in other PTSD symptoms or depression. Patients report that their "fuse" seems longer and that they see things that used to make them angry but somehow do not bother them as much. This reduced inclination toward anger frequently occurs within a few days of starting treatment and sometimes occurs at lower than usual doses, consistent with the lower dosing of reboxetine conducted by Harmer et al. Sometimes it is the patient's spouse, not the patient, who first notices that the patient seems less angry. Sometimes the ameliorative effect of SSRIs on anger is reaffirmed with medication discontinuation. I have had spouses correctly suspect that their husband was secretly medication noncompliant based on their perception of his increased anger. One patient, a former Vietnam medic, was able to articulate a change in his perceptions with sertraline discontinuation. Within days, he perceived that people around him were suddenly "lots more angry and difficult." He realized, of course, that this was unlikely and that it was his appraisal of others that had suddenly changed.