The region-of-interest-based approach was chosen due to strong evidence for the involvement of the ventral striatum in the mediation of starvation dependence. Beyond the region-of-interest analysis, we also reported on a whole-brain analysis that tested the group-by-stimulus interaction of interest but did not reveal any further brain regions (p. 210). The lack of effects in cognitive cortices is in contrast to a previous study on anorexia nervosa that showed, with disease unrelated rewards, increased activation in prefrontal and parietal regions (1). It may be this difference in stimulus material that explains the discrepancy among observations. Possible further influences of different states of illness and recovery are an interesting point. The presence of symptoms in children at risk for anorexia nervosa and in recovered patients has led to the concept of enduring trait variables that are present in both acute and recovered states (1, 2). Thus, even when patients have recovered, usually defined by a changed status of malnutrition, enduring trait-related alterations, such as altered dopamine function or increased drive for thinness, do persist. We strongly agree that possible alterations of these variables and corresponding neural processes should be tracked in longitudinal studies, which we mentioned in our article (p. 211).