A 5-year study of 3,521 randomly selected older adults confirms that clinically significant depression is associated with the development of diabetes mellitus. Campayo et al. (p. 580) report that depression and diabetes were assessed through standardized interviews and that treatment with antidepressants was not related to the increased diabetes risk. Instead, new-onset diabetes was associated with nonsevere depression, as well as persistent or untreated depression, body mass index, and a family history of diabetes. The editorial by Dr. Constantine Lyketsos on p. 496 points out that "somewhat unexpectedly, less severe depression was associated with a higher risk of diabetes, compared to severe depression, perhaps because it was less likely to be treated."