In this issue of the Journal, a new study conducted by Satterthwaite et al. (7) addresses cognition-emotion interaction in schizophrenia with a functional magnetic resonance imaging (fMRI) experiment of an emotional face-recognition paradigm. Specifically, the participants performed an old versus new recognition memory task for neutral faces that they had previously seen with emotional expressions (threat versus nonthreat). Hence, this task required the participants to remember the faces while ignoring the past emotional context under which they learned them. The main hypothesis was that an imbalance between emotion and cognition would be manifested as an inverse relationship between limbic and cortical systems, such that as paranoid symptoms become more severe, limbic responses would predominate at the expense of cortical recruitment. Indeed, there was reduced activation of frontoparietal regions involved in recognition memory in individuals with schizophrenia relative to healthy comparison subjects, and this decreased activity was associated with increased symptom severity. Increased activity in limbic regions when processing faces that were previously displayed as threatening was associated with general symptom severity and paranoia in patients. Lastly, functional connectivity analysis suggests that in healthy participants, increased limbic activity was coupled with decreased activity in cortical regions, but this inverse relationship appears to be disrupted in schizophrenia. Overall, these findings suggest that abnormal processing of threat-related signals in the environment may exacerbate cognitive impairment in schizophrenia by tilting the cognition-emotion balance toward the limbic circuit, and they highlight the role of emotional context in cognitive deficits in schizophrenia. However, there are missing pieces in the puzzle with respect to functional connectivity analysis. First of all, it is unknown how increased or reduced functional connectivity translates to behavior, and, second, it is equally unclear how reduced cognitive capacity might influence emotion. In other words, the authors have addressed "cognition versus emotion" from one end. It would be informative to consider traversing the opposite direction as well. Nevertheless, this work highlights the importance of examining cognitive and emotional processes in tandem.