A large study demonstrates that neurocognitive abilities in African Americans are inherited and are affected by schizophrenia, as they are in Caucasians. Calkins et al. (CME, p. 459) analyzed functioning in 10 neurocognitive domains for 610 African American patients with schizophrenia or schizoaffective disorder, their relatives, and community comparison subjects. The patients were slower and less accurate in most domains than their relatives—both with and without other psychiatric disorders—and the relatives were more impaired than the comparison subjects. These abilities may therefore provide quantifiable markers of schizophrenia, or endophenotypes, that could be used to identify individuals for genetics research.