The rate of depression was 10% in children, adolescents, and young adults 21 months after the death of a parent, compared to 2% in nonbereaved comparison subjects. Depression at 21 months was most strongly related to depression at the 9-month follow-up conducted previously by Brent et al. (p. 786). Depression during the second year after the loss was associated with parental death by suicide, loss of a mother, severe grief reaction, negative coping strategies, low self-esteem, and blaming others for the parent’s death. Subjects whose parent died by suicide also had a higher rate of alcohol or substance abuse than nonbereaved subjects. Dr. Katherine Shear clarifies grief and depression in an editorial on p. 746.