0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letters to the Editor   |    
Dr. Rais Replies
MONICA RAIS
Am J Psychiatry 2008;165:1358-1358. doi:10.1176/appi.ajp.2008.08040618r
text A A A

To the Editor: Drs. Zullino, Waber, and Khazaal state that evidence for a causal correlation between cannabis use and schizophrenia was lacking in our study. Indeed, we could not address the direction of causality. Nevertheless, in our opinion, finding a relationship between cannabis use and brain volume loss in patients with first-episode schizophrenia was a first step toward examining a possible causality. We agree with Dr. Zullino et al. that, theoretically, gray matter reduction might be a common effect of several addictive drugs, specifically alcohol and tobacco. However, as described in our article, alcohol use was not significantly different between the three study groups. Moreover, we examined the effect of tobacco smoking among noncannabis using patients by applying a general linear model univariate analysis of covariance, with percentage gray matter volume changes as a dependent variable; group (noncannabis using patients, smokers, and nonsmokers) as an independent variable; and age, gender, and intracranial volume as covariates. Smokers and nonsmokers in the noncannabis using schizophrenia group did not differ significantly in gray matter change over the follow-up interval (F=4.81, df=4, 27, p=0.49). Thus, it is unlikely that the effect reported in our study could be attributed to the concomitant smoking of cigarettes.

+The author’s disclosures accompany the original article.

+This letter (doi: 10.1176/appi.ajp.2008.08040618r) was accepted for publication in June 2008.

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition > Chapter 45.  >
The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 58.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 16.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 15.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines
PubMed Articles