GRIK4 codes for the KA1 subunit of kainate receptors (KARs). Kainate receptors are tetrameric assemblies of subunits similar in structure to the other ionotropic glutamate receptors, AMPA and NMDA. Their function is less well understood than that of AMPA and NMDA receptors, but a growing knowledge base suggests they are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABA-ergic interneurons. Five subunits can assemble to form KARs; GluR5 (coded by GRIK1), GluR6 (coded by GRIK2), and GluR7 (coded by GRIK3) are the low-affinity subunits, with the GluR5 or GluR6 subunit determining the receptor’s permeability to Ca++, and KA1 and KA2 are the high-affinity subunits. The number of subunits and their mix in KARs add to the variety of KAR properties throughout brain. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Presynaptically, the receptors act as both facilitatory and inhibitory autoreceptors. Some kainate receptors also function heterosynaptically, sensing extrasynaptic glutamate. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in human brain diseases. Their involvement in seizure disorders is supported by a high sensitivity of hippocampal tissue to kainate in animal models and the resistance of GluR6 knockout animals to kainate-induced seizures. Topiramate, an anticonvulsant, antagonizes the GluR5 subunit of the KAR and may act there to attenuate seizures. Clinical trials are evaluating the effects of GluR5 antagonists in migraine. GluR5 antagonists also have antinociceptive activity. GRIK1 is located on 21q22.1, the region implicated in Down’s syndrome. GRIK2 has shown significant linkage with autism. GRIK3 has been linked to schizophrenia. The crystal structures of the GluR5 and GluR6 subunits have been solved (figures), but the KA1 and KA2 subtypes have resisted structural analysis.