The late addition of ziprasidone limited its study period to less than those of the other drugs. Even so, these findings as well as earlier work militate for a more thorough evaluation of ziprasidone and the other atypical antipsychotics that merit investigation under similar conditions (2). The dose range of olanzapine exceeded the manufacturer’s recommendation (2.5–20 mg/day) by a factor of 150%, such that the mean dose, 20.8 mg/day, contrasted sharply with the other atypical medications, whose means remained substantially below their manufacturers’ recommended maxima. Perphenazine use reached its manufacturer’s suggested maximum for hospitalized patients, 32 mg/day, but not the absolute safe limit of 64 mg/day (perphenazine prescribing information from Geneva Pharmaceuticals, Inc., Broomfield, Colo.). Thus, olanzapine realized an advantage the other medications did not enjoy.