Dr. Goldney would like us to clarify the meaning of "appropriate precautions" and asks whether this implies the exclusion of those who are suicidal. Indeed, in most studies, suicidal patients are explicitly excluded. However, this is not the meaning of "appropriate precautions." By "appropriate precautions," we mean the usual precautions that are taken before and/or during the studies (the inclusion and exclusion criteria, careful monitoring, etc.). When these appropriate precautions are taken, we have shown that concern about the risk of suicidal behavior is not an argument against the conduct of placebo-controlled trials for these indications. This conclusion is evidenced based and therefore credible, logical, and, indeed, ethical.