The selective serotonin reuptake inhibitor (SSRI) antidepressants do not work for all depressed people. Slowed motor activity and verbal processing in a subgroup of depressed patients suggest abnormalities in dopamine, rather than serotonin, and this subgroup appears less likely to respond to SSRIs. Now there may be a practical clinical tool to spot SSRI nonresponders before they undergo weeks of ineffective treatment and become discouraged. The FAS test-listing as many words as possible in 1 minute that begin with "F," with "A," and with "S"-reveals impaired verbal fluency. Taylor et al. (p. 73) gave the test to patients before a trial of fluoxetine, an SSRI. Of patients scoring below the norm, only 40% responded to fluoxetine, compared to 100% of those scoring above the norm. All of the nonresponders scored below the norm. If it is established that non-SSRI antidepressants work better for this subgroup, this 5-minute test could bring help to many patients faster, before they abandon treatment.