To the Editor: Aripiprazole is a second-generation antipsychotic approved for the treatment of schizophrenia and increasingly used in bipolar patients. It acts as a partial agonist at dopamine receptors and displays high affinity for serotonin 5-HT1A and 5-HT2A receptors on 5-HT neurons, producing partial agonism and antagonism, respectively. Its side effects include insomnia, anxiety, headaches, nausea, vomiting, and somnolence (1). Aripiprazole’s affinity for α1-adrenergic and muscarinic receptors is low; consequently, cardiovascular adverse effects are rare. Only postural hypotension (without clinical symptoms) has been described in elderly patients (2). However, we report a case of hypertensive crisis triggered by aripiprazole.