To the Editor: I would like to comment on a study in the April issue by Stephen V. Faraone, Ph.D., et al. (1). It is surprising to me that a study that did not produce a single positive result could elicit such broad-sweeping conclusions from its authors. Is it really acceptable science to tout findings that are nonsignificant but suggestive? We have seen nearly two decades of genetic linkage analysis studies and, as the author of another article in the same issue of the Journal concedes, there has yet to be a "confirmed gene related to bipolar disorder" (2, p. 595). One would think that this fact would make genetic researchers more circumspect.