There are certain methodological shortcomings in this systematic review. First, only the MEDLINE database was searched for studies in this area. A thorough search of other databases, including studies published in nonindexed journals, could have yielded more studies. Second, the studies were not assessed for their methodological qualities, and no definitive criteria were used that are usually recommended as an integral part of a systematic review (2, 3). Only three of the 11 studies included were randomized, double-blind, controlled trials; the rest were open-label studies. Even among these three, one was a study involving demented patients. Third, the studies included had used different modes of drug administration (injectable/oral), comprised patients of different age extremes, and included patients who had illnesses such as dementia and Parkinson’s disease—all of which have a bearing on the development of tardive dyskinesia.