Sadness, bereavement, and clinical depression are distinct emotional experiences. Abnormalities in brain activity among depressed people may not extend to sadness and grief, and brain functioning during induced sadness reflects the subject’s memory of a sad state, not the real thing. Najib et al. (p. 2245) measured brain activity in women currently grieving the loss of a romantic relationship. Increased activity with sad thoughts of the ex-lover was generally found in posterior brain regions, and decreases were more prominent on the left and in anterior regions. In nearly all regions showing decreases with sad thoughts (grief state), decreases were greater in women with higher baseline grief ratings. The findings largely parallel previous results for sadness and depression but differ in some respects, confirming the uniqueness of the grief state.