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Letter to the Editor   |    
Dr. Kugaya and Colleagues Reply
AKIRA KUGAYA, M.D., Ph.D.; C. NEILL EPPERSON, M.D.; CHRISTOPHER H. van DYCK, M.D.; MASAHIRO FUJITA, M.D., Ph.D.; ROBERT B. INNIS, M.D., Ph.D.
Am J Psychiatry 2004;161:2136-a-2136. doi:10.1176/appi.ajp.161.11.2136-a
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To the Editor: We agree with the points raised in the letter by Dr. Moses-Kolko et al. To clarify, we applied stringent statistical criteria (statistical parametric mapping voxel threshold of p<0.01) in our study and identified a large and significant increase (>5000 pixels with corrected p=0.001) in the right frontal area of the brain. Differences in sample size or methodology (including statistical parametric mapping statistics) may explain some discrepancies between the studies in affected brain areas.

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