Another issue of concern is assessment variations. Although the authors attempted to control the effect of intercentric assessment variations by loading study centers as a covariate in analysis of covariance, which we consider an indirect way of addressing interrater reliability, they failed to address the details of intracentric assessment. Considering that this is a multicentric study, such a description of intracentric assessment variations, if any, is important for interpretation of the results. In this study (1), use of analysis of covariance to control the effect of baseline psychopathology is not adequately justified (1), as there was no mention that baseline psychopathological scores differed significantly between groups. A further issue, under the safety analysis section, the authors could have provided the details (mean dose and pattern) of anticholinergic medication use.