To the Editor: We recently completed a study examining the impact of depression and antidepressants on obstetrical outcome (1). This study was approved by UCLA’s institutional review board, and written informed consent was obtained from all subjects. Although not a primary outcome variable, we found that 46 women with a history of depression had a significantly higher mean number of prior therapeutic (elective) abortions than 16 women without a history of depression (mean=0.78, SD=1.11, versus mean=0.31, SD=0.60, respectively) (robust t=2.11, Satterthwaite df=48.9, p=0.04; Poisson regression χ2=4.63, df=1, p=0.03). The mean number of prior pregnancies and spontaneous abortions did not differ. Upon closer inspection of the literature, we observed that in two other studies of antidepressants and obstetrical outcome in which abortion-related statistics were reported (2, 3), similar findings were presented but not discussed. Chambers et al. (2) found that spontaneous abortion rates were comparable but that elective abortion rates were significantly higher in fluoxetine-treated pregnant women (9.6%) in relation to comparison subjects (2.7%) (p=0.002). Kulin et al. (2) found that women who took selective serotonin reuptake inhibitors during pregnancy had similar rates of prior spontaneous abortions but higher rates of prior elective abortions in relation to comparison subjects (24% versus 13%, p=0.03). While the reason for these differences is unclear, the consistency of the finding is concerning and merits attention.