There is much that is good about this book, however, and the editors should be congratulated for spotting an up-and-coming and promising area of psychiatry and producing a volume that is accessible and attractively presented. For a single reference volume on the area, there is no better source. So, after the final whistle has blown, is depression in older people a cerebrovascular disease? The vascular depression hypothesis is appealingly simple and should be easily testable. To my surprise, even after following the editors’ postmatch punditry, I didn’t really reach a definite conclusion. This is not the book’s fault. Lines of evidence from widely disparate areas of medicine and neuroscience are sometimes hard to piece together, particularly when the data are still awaiting confirmatory replication. But there’s always next season, and I am sure that there will be a demand for further editions of this book. As the field matures and consolidates, Vascular Disease and Affective Disorders should deliver some more great goals and some decisive results.