We found higher triglyceride levels in the 17 patients who were ≤20 years old at the beginning of schizophrenia (mean=1.7, SD=0.7) compared with the 14 patients with later onset (mean=1.4, SD=0.9) or the 5,453 nonhospitalized comparison subjects (mean=1.2, SD=0.7). The Mann-Whitney U test showed a significant difference between the first and third groups (p<0.01), and Pearson’s correlation coefficient showed a negative correlation between the age at onset and the level of serum triglycerides (r=–0.35, p=0.05). One explanation may be a genetic linkage since hypertriglyceridemia may be related to the more severe forms of schizophrenia. On the other hand, cognitive disorders in these patients may lead to a poor diet, and a more prolonged exposure to antipsychotics may further raise triglyceride levels. A recent study demonstrated that both novel and conventional antipsychotics may be associated with dyslipidemia but also that patients are infrequently monitored for these parameters (4). Our finding may imply that patients with early-onset schizophrenia are at special risk for the cardiovascular complications of hypertriglyceridemia, and their serum lipid levels should be monitored regularly as part of their treatment.