Positive correlations of VBR and local Jacobian determinant were found for the lateral ventricles (maximum voxel: x=–12, y=–10, z=26; r=–0.93, df=36, p<0.001) as expected (4) but also parts of the third ventricle. A positive correlation means that local volume increases with larger VBR values. For negative correlations (higher VBR related to local shrinkage) (F1), the strongest effects were found in the left medial/posterior thalamus (x=–8, y=–16, z=12; r=–0.80, df=36, p<0.001), right thalamus (x=12, y=–16, z=12; r=–0.66, df=36, p<0.01), left superior temporal gyrus (x=–58, y=2, z=–4; r=–0.61, df=36, p<0.01), left putamen (x=–26, y=6, z=–12; r=–0.72, df=36, p<0.01) and the right putamen (x=36, y=–10, z=0; r=–0.67, df=36, p<0.01). The shrinkage in the putamen may extend into the insula. Some small clusters (right middle temporal gyrus, posterior cingulate, right cerebellum) comprised only few voxels, thus failing to reach the spatial extent threshold of p<0.05.
No significant differences were found in hippocampal areas adjacent to the temporal horns of the ventricles or the corpus callosum.