Marvin Herz and Stephen Marder, two eminent, internationally known schizophrenia researchers and experienced clinicians, have written a very practical clinician- and patient-focused handbook about schizophrenia and its treatment. Herz, Professor of Psychiatry at Rochester School of Medicine in New York and a previous chairman of the Department of Psychiatry of the State University of New York at Buffalo, is known for his research in relapse prodromes; he attempts to identify schizophrenia patients at high risk of relapse. Marder, an outstanding psychopharmacological clinical researcher and clinician, is Professor and Vice-Chair, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, and Director, U.S. Department of Veterans Affairs (VA) VISN 22 Mental Illness Research Education and Clinical Center. Together they bring 60 years of clinical and research experience dedicated to the study and care of schizophrenia. Both are well-funded researchers (e.g., the National Institute of Mental Health and the VA). They review the latest treatment literature, give case vignettes, and share what they have learned and found effective, while providing background information on the latest hypotheses of the disorder (briefly) and how the clinician may be able to influence positively the lives of patients. Their caring and clinical expertise comes through loud and clear. By writing the book themselves rather than collecting a number of collaborators, they have come up with a coherent and comprehensive approach to the treatment of schizophrenia. It is a testimony of the breadth of their experience and how the field has brightened for our patients and their families in recent years.