Part 3 of the book applies the model to several psychiatric syndromes. The internalizing disorders such as mood and anxiety disorders are discussed in great detail in chapter 9, which includes a review of the literature from animal as well as human studies. In addition, the author pays due attention to genetics as well as twin studies to propose that the shared genetic liability in these disorders is the sensitivity to environmental factors. In chapter 10, she extensively explores child behavior under the concept of externalizing disorders, including the origin of disruptive behaviors in the complex interaction of genetic and environmental factors. The role of affect dysregulation in disorders such as conduct disorder, adult antisocial personality disorder, oppositional defiant disorder, and attention deficit hyperactivity disorder is explored. A separate chapter is devoted to the psychotic disorders, including schizophrenia. The author takes up basic issues of definition, focusing on the disturbances of affect and cognition and exploring the relationship of psychotic disorders to mood disorders. She also deals with neurobiology in considerable detail, discussing the issue of negative and positive symptoms and the current thinking in this regard.