The pace of research in Alzheimer’s disease is accelerating. Particularly on the basic science front, each day there are reports that seem to bring new insights and challenges to our understanding of not only what Alzheimer’s disease is but how the brain works. With this breakneck pace, how can one keep up? The editors of this work offer one answer, an annual that seeks to "bridge basic sciences and clinical practice in the realm of dementia." Although this would seem to be a fairly daunting task, the editors have largely succeeded in this goal by assembling a slim, focused review of 10 key subjects in Alzheimer’s disease research.