0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Book Forum: Schizophrenia   |    
The Neuropathology of Schizophrenia
PETER FALKAI, M.D.
Am J Psychiatry 2002;159:1451-1451. doi:10.1176/appi.ajp.159.8.1451
View Author and Article Information
Bonn, Germany

Edited by Paul J. Harrison and Gareth W. Roberts. New York, Oxford University Press, 2000, 374 pp., $69.95.

text A A A

This book comprises 15 chapters on different aspects of the neuropathology of schizophrenia. After a review of the macroscopic findings in chapter 1, some specific aspects are reviewed in chapters 2 to 6, including hippocampal, cortical, and synaptic pathology as well as the question of gliosis and cerebral asymmetry. At the end of each chapter the published data are critically summarized and a future perspective is outlined. In chapters 7 to 12, additional aspects from imaging and other, related diseases are presented. Additionally, the knowledge on cortical development and the organization of cortical circuitry is summarized. The concluding chapters deal with methodological issues, the consequence of neuropathological findings for the treatment of schizophrenia, and a skeptical view of the neuropathology of schizophrenia in general.

Trying to place a value on this very well-conceptualized and well-written book, one has to know that since the first neuropathological study on schizophrenia in 1898 by Alois Alzheimer, only summary chapters have been written to bring together the published data on what is regarded as a very controversial area of schizophrenia research. The value of this book, however, is that it not only critically reviews our current knowledge concerning different aspects of the neuropathology of schizophrenia but also discusses details that are vital to put the data within the conceptual framework of the neurobiology of schizophrenia. In addition to looking at gliosis and neurodevelopment, the chapter authors present relevant literature on cortical development and animal models. Finally, having some chapters specifically dedicated to methodological aspects in this area adds another important perspective to this work.

In conclusion, this is a very comprehensive book covering all relevant areas of the neuropathology of schizophrenia as currently understood. It is not only very valuable to readers interested in the neuropathology of schizophrenia, but it is also an interesting, readable introduction to the neurobiology of this severe mental disorder.

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 2.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 9.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 6.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 10.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines
PubMed Articles