All in all, this volume shows well the strengths and weaknesses of contemporary psychiatry. We feel justifiably proud of the advances in our understanding of the functioning of the normal brain, our ability to measure the anatomy and function of the brain, and the ever-increasing mass of knowledge about psychopharmacology. What we avoid facing, in our hubris over psychiatry entering the arena of a true neuroscience, is that this new knowledge has not done much to improve our ability to treat patients. We have not shown that the new antipsychotics improve symptoms to a significantly greater extent than chlorpromazine did in the 1950s, or that our psychosocial treatments and social policies have improved the lot of patients with chronic mental disorders, or, for that matter, that all the new drugs for mood and anxiety disorders work better than the few we had in the 1960s. There are some exceptions. Clozapine has added something new, but it hasn’t had the large effect we thought it would.