Overall, I found this concise guide to be very readable and useful. I now carry it with me to work. I would like to add a few comments about two issues that I think are important in using psychiatric medications. First, I often see patients started on two psychiatric drugs, like olanzapine and fluoxetine, at the same time, and I think this is poor practice unless it is an acute situation. How do you know what drug is working? Psychiatric medications should be changed one at a time so you can better judge their effect. Second, it has been my experience that most severely ill psychiatric patients can usually be managed with one, two, or, at most, three medications. For example, an antidepressant with an atypical neuroleptic for depression and agitation, a mood stabilizer with an atypical neuroleptic for agitated psychosis, and a short-acting benzodiazepine with an atypical neuroleptic for agitated Huntington’s chorea can often be effective. It is my experience that if you use more than three psychiatric medications you have problems with increased agitation and oversedation.