Discussing "Prozac and Other Placebos" (chapter 4), Horgan favors Fisher and Greenberg (5), who suggested a null hypothesis of antidepressant efficacy, and Roger Brown’s urging of placebo trials (6). He mentions Donald Klein’s "horror" about this, but the rebuttal of Quitkin et al. (7) and the debate about placebo trials in the April 2000 Archives of General Psychiatry(8, 9) appeared after the book’s publication. Horgan cites so many negative findings and side effects for lithium and typical and atypical antipsychotics that no one reading this book would be likely to comply with treatment. Although he is clearly impressed with the "electroshock" (electrocortical treatment) suite and bearing of psychologist Harold Sackheim at New York State Psychiatric Institute, he reports that "fewer than eight out of 100 typical ECT recipients became well and stayed well without further intervention—even when treated at what may be the world’s most sophisticated shock therapy clinic" (p. 134). He adds, however, that "unlike [Peter] Breggin I believe that biological remedies can benefit some of the people some of the time, just as talk therapy can (even if the placebo effect accounts for most of the benefits)" (p. 134). Horgan then confesses his own "brush with depression" (p. 135) in college, which he believes was psychologically triggered and which he self-medicated with "copious amounts of alcohol and drugs" (p. 135). He says that if he became depressed again, he would "try psychotherapy first, and then antidepressants. If they didn’t work, and if my condition worsened, I might give the shock therapy expert Harold Sackheim a call" (p. 135). Horgan does not speculate whether listening to Prozac could produce less nihilistic books entitled No End to Science or The Discovered Mind. I have not recommended this book to patients because of its negative placebo value.